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All Journal Majalah Kesehatan FKUB Molecular and Cellular Biomedical Sciences (MCBS) Jurnal SOLMA Journal of Tropical Pharmacy and Chemistry Jurnal Kebidanan Mutiara Mahakam Jurnal Kedokteran Mulawarman Jurnal Sains dan Kesehatan
Meiliati Aminyoto
Universitas Mulawarman
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Dentistry Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Public Health Other

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Journal : Journal of Tropical Pharmacy and Chemistry

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Aphrodisiac Activity of Ethanol Extract of Cratoxylum sumatranum (JACK) Blume Stems on Isolated Rat Corpus cavernosum Sjarif Ismail; Meiliati Aminyoto
Journal of Tropical Pharmacy and Chemistry Vol. 4 No. 3 (2018): Journal of Tropical Pharmacy and Chemistry
Publisher : Faculty of Pharmacy, Universitas Mulawarman, Samarinda, Indonesia, 75117, Gedung Administrasi Fakultas Farmasi Jl. Penajam, Kampus UNMUL Gunung Kelua, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (350.93 KB) | DOI: 10.25026/jtpc.v4i3.150

Abstract

Cratoxylum sumatranum (Jack) Blume of the Hypericaceae family is known as “Bentaleng” by Dayak Benuaq. In ethnobotany, Cratoxylum sumatranum stems (CSS) is used as energy drink or aphrodisiac, but its effect has not been scientifically proven. Research objective to study the aphrodisiac activity of CSS extract by screening the aphrodisiac activity in vitro. Method: CSS was collected from Kutai Kertanegara Regency, East Kalimantan Province. Extraction was by maceration with ethanol solvent for three days. Re-maceration was done twice. In vitro screening of aphrodisiac activity used isolated rat corpus cavernosum. The organ was placed into a 10 mL chamber containing Krebs-Henselheit solution at pH 7.4, 37°C and aerated with carbogen gas. After acclimation, a contraction test was performed with phenylephrine solution and after reaching the peak of contraction at plateau the Control (solvent extract) or CSS ethanol extract was administerd at cumulatively increased concentration. Vasodilation activity was known if the contraction response was decreased after the extract’s administration and expressed in percent contraction with negative value. Results: CSS ethanol extract induce vasodilatory response on rat Corpus cavernosum blood vessels. Vasodilation activity is increasing with increasing concentration of extract given compared to Control. Conclusion the aphrodisiac activity of CSS ethanol extracts is directly through the vasodilation action mechanism on blood vessels in the rat corpus cavernosum.
Co-Authors Aegirine Rafilah Dahlan Ainur Basirah Mulya Amalia Rizkiannur Putri Annisa Muhyi Arfian Deny Prakoso Bilqis Faiqotun Nabilah Dilan Cristian Bungin Eva Rachmi Evi Fitriany Fadzilah Nur Qolbiyah Fikriah, Ika Khemasili Kosala Miftahul Jannah Mita Maulida Rifqiya Faiza Nataniel Tandirogang Nursaci Mardania Nurul Hasanah Prisilia, Cindy Rahmat Bakhtiar Riries Choiru Pramulia Yudia Sapta Rahayuning Ratri Sayyid Muhammad Sahil Haikal Silvanus Giovanny Bunga Allo Sjarif Ismail Swandari Paramita Tri Wulandari Yadi Yadi Yadi Yasir Yuliana Kartika Ningrum Yuliana Rahmah Retnaningrum Yuniati Yuniati